Depression that hasn't responded to antidepressants isn't the end of the road.

PMC Psychedelic treats major depressive disorder, postpartum depression, and the depressive phase of bipolar disorder using FDA-approved psychedelic medicine in Port Chester, NY.

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The types of depression we treat.

Depression is not a single condition. The presentation, cause, and best treatment approach varies. Below are the three primary types we treat at PMC Psychedelic.

Major Depressive Disorder (MDD)

Persistent depressive episodes that significantly impact daily function. Often defined by sadness, loss of interest, fatigue, and difficulty concentrating.

Postpartum Depression

Depression that develops after childbirth, ranging from persistent sadness to emotional numbness and difficulty bonding. Can affect parents at any point in the first year.

Bipolar Depression (Depressive Phase)

The low phase of bipolar disorder, characterized by the same symptoms as MDD. Ketamine and Spravato can treat the depressive episode without triggering a manic phase.

How PMC Psychedelic treats depression.

Our treatments target the brain's glutamate system — a different pathway than the serotonin and dopamine mechanisms of traditional antidepressants. This is why they work for patients who have not responded to conventional approaches.

Primary · Insurance Covered

Spravato® (Esketamine)

FDA-approved for MDD — including treatment-resistant cases.
Nasal spray, self-administered in-office under supervision.
Covered by most PPO plans — we verify before your first visit.
Fast-acting: many patients notice improvement within 24 to 48 hours.

Learn About Spravato

Secondary · Out-of-Pocket

Ketamine IV Infusion

Strong clinical evidence for MDD, bipolar depression, and postpartum cases.
IV delivery allows precise, controlled dosing.
Effective option when Spravato is not covered or not preferred.
No insurance required — paid out of pocket.

Learn About Ketamine IV

Not sure which treatment fits your situation? Start with a consultation — Dr. Rueda reviews every patient individually before making any recommendation.

Postpartum depression is more than 'baby blues.'

Postpartum depression is a clinically recognized condition — not a mood or a phase. It can begin during pregnancy or within the first year after delivery, and it affects both the parent and the developing child's environment.

Standard antidepressants are often the first-line recommendation, but they can take weeks to work and may not be appropriate for all patients, particularly those who are breastfeeding. Ketamine-based treatments offer faster relief and are evaluated on a case-by-case basis by Dr. Rueda.

PMC treats postpartum depression in the context of broader depressive episodes.
Both Spravato and Ketamine IV are discussed for appropriateness during your consultation.
Dr. Rueda reviews breastfeeding status, medications, and medical history before recommending anything.
We coordinate with your OB-GYN or midwife if you are currently receiving postpartum care.

Treating the low without triggering the high.

For patients with bipolar disorder, treating the depressive phase comes with a specific risk: standard antidepressants are known to trigger or worsen manic and hypomanic episodes. This leaves many bipolar patients with few safe options for depression relief.

Ketamine-based treatments work through the glutamate system rather than serotonin pathways — which is why they can produce meaningful relief from bipolar depression without the mania-triggering risk associated with SSRIs. Dr. Rueda evaluates every bipolar patient individually and reviews their full medication regimen, including any mood stabilizers, before recommending treatment.

PMC treats the depressive phase of bipolar I and bipolar II disorder.
Ketamine and Spravato are not mood stabilizers — they do not treat mania.
Not known to trigger manic episodes the way SSRIs can.
We coordinate with your psychiatrist or prescribing provider throughout treatment.

What our patients experience.

75–83%

Efficacy Rate

For treatment-resistant depression and anxiety

24–48 hrs

Time to First Improvement

For many patients after early sessions

FDA

Approved Treatments Only

No experimental protocols

Results represent improvement, not a cure. Psychedelic medicine does not work for every patient, and outcomes vary by individual, condition severity, and treatment history.

Common questions.

Antidepressants work by adjusting serotonin, norepinephrine, or dopamine levels and typically take 4 to 6 weeks to produce any measurable change. Spravato and ketamine target the glutamate system — a completely different pathway — and produce results within hours to days for most patients. This is why they work for people who have not responded to standard antidepressants.

This is evaluated individually by Dr. Rueda based on your specific situation, including whether you are breastfeeding, your current medications, and your medical history. Please raise this directly during your consultation. We never recommend a treatment before completing a thorough review of your full clinical picture.

Ketamine and Spravato have been used in patients with bipolar disorder specifically to treat the depressive phase. They are not known to trigger manic episodes the way some antidepressants can. Dr. Rueda evaluates each bipolar patient individually before treatment begins — including their current mood stabilizer regimen.

Spravato is FDA-approved for major depressive disorder and is covered by most PPO insurance plans. We verify your coverage before your first appointment. Ketamine IV is paid out of pocket.

We typically see new consultation requests within one to two weeks. Contact us directly to discuss timing.

There are options you may not have tried yet.

Request a consult with Dr. Rueda's team. We will review your history, discuss your specific presentation, verify your insurance, and give you an honest assessment of whether our treatments are the right fit.