| Phase | Frequency | What to Expect |
|---|---|---|
| Induction Phase | Twice per week | Weeks 1–4. Two sessions per week, approximately 2 hours each. This is the most intensive phase — designed to establish response. |
| Continuation Phase | Once per week | Months 2-3. Sessions reduce to once weekly for four weeks as your response stabilizes. |
| Maintenance Phase | As needed | Ongoing. Frequency is determined collaboratively based on how long your improvement lasts. Many patients continue monthly or bi-monthly. |
Clinical trials show improvement rates of 70% or higher in patients with treatment-resistant depression. At PMC, our patient outcomes align with that range. We use the word ‘improvement’ rather than ‘cure’ — psychedelic medicine is not a guaranteed fix, but it has produced meaningful, lasting relief for a large majority of our patients who had not responded to other treatments.
Most PPO insurance plans cover Spravato. We verify your coverage before your first appointment at no cost to you. HMO plans are not accepted. Call us or submit an insurance check request to get a clear answer specific to your plan.
Each session is approximately two hours. During that time, you’ll self-administer the nasal spray under supervision, then rest while our clinical team monitors you. You should plan for the full two hours and arrange a ride home — you cannot drive for the remainder of the day after a session.
The standard induction phase is two sessions per week for four weeks (eight sessions total). After that, most patients move to once weekly for a month, then to a maintenance schedule based on how long their improvement holds. Many patients continue treatment on a monthly or bi-monthly basis long-term.
Yes. Spravato was originally approved as an add-on to oral antidepressants and is now also approved as a standalone therapy. Dr. Rueda will review your current medications and make a recommendation during your consultation.
Some patients experience a temporary dissociative sensation — a dreamlike or slightly detached feeling — during the session. This is normal and typically resolves within the two-hour monitoring period. Blood pressure is monitored throughout. The experience is different for everyone.
No referral is required to book a consultation. However, if you’re working with a psychiatrist or therapist, we’re happy to coordinate care with your provider to ensure continuity.
