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Spravato Vs Ketamine: How Do They Compare?

Spravato Vs Ketamine How Do They Compare legally

Spravato Vs Ketamine: How Do They Compare?


Key Takeaways

  • Spravato is a form of ketamine called esketamine, which is inhaled nasally and is approved by the FDA for use in treatment-resistant depression.
  • Spravato is typically prescribed in combination with other anti-depressants and has the main benefit of rapid effectiveness in relieving symptoms.
  • The administration of Spravato involves the patient inhaling it nasally through puffs to each nostril, with the dose established by the practitioner and requiring multiple devices.
  • The duration of Spravato treatment varies based on individual needs and progress, with regular evaluations conducted to monitor treatment effectiveness.

What is Ketamine?

You might know ketamine as a powerful anesthetic, but it’s also used in the treatment of various mental health conditions. This dissociative anesthetic distorts perception of sight and sound, creating feelings of disconnection and a lack of control. Despite these disconcerting effects, it’s employed for its ability to provide pain relief and sedation during medical procedures.

On the streets, ketamine goes by a variety of names like Cat Tranquilizer, Kit Kat, or Jet K. It’s not just used in a medical setting; it’s also abused recreationally for its hallucinogenic effects. Ketamine can be injected, mixed with liquids for consumption, snorted as a powder, mixed in drinks, or even smoked. It’s a versatile drug with potent effects that are often sought after for the wrong reasons.

When used inappropriately, ketamine does more harm than good. It can cause agitation, depression, and cognitive difficulties. In some cases, it can lead to unconsciousness and even amnesia. Physically, it can cause involuntary rapid eye movement, dilated pupils, and muscle stiffness.

Overdosing on ketamine is a serious risk when abused, leading to unconsciousness and dangerously slowed breathing. It’s important to understand the potential dangers and impacts of this drug when used outside of a controlled, medical context.

However, when used appropriately and under medical supervision, ketamine can be a powerful tool for pain relief and the treatment of certain mental health conditions.

What is Spravato (Esketamine)?

In the realm of mental health treatments, Spravato, also known as Esketamine, is a prescription nasal spray that’s used in conjunction with an oral antidepressant to tackle treatment-resistant depression. It’s a Schedule III controlled substance, which means it has a potential for abuse and dependence, but its benefits can be life-changing for those who’ve found no relief from other treatments.

Spravato is self-administered under the watchful eye of a healthcare provider, starting with a recommended dose of 56 mg. This dose can be adjusted based on your response, up to 84 mg or 112 mg. The nasal spray is used twice a week for the first four weeks, then once a week or every two weeks thereafter.

While taking Spravato, you’ll need to be aware of potential side effects, which can include dizziness, nausea, and even dissociation. It can also cause sedation and impair your cognitive and motor functions, so you’re advised not to drive or operate machinery for at least 24 hours after administration.

Despite these precautions, clinical trials have shown significant improvement in depressive symptoms with Spravato. Some patients have even reported effects as early as 24 hours after the first dose. However, it’s important to note that Spravato is only available through a restricted distribution program, and long-term effects are still under study.

Mode of Administration

When it comes to the mode of administration, both Spravato and ketamine have their unique methods.

You’ll find that Spravato is typically self-administered under medical supervision through nasal inhalation.

On the other hand, ketamine is often delivered via an intravenous infusion in a clinical setting.


With a focus on Ketamine, it’s essential to understand that unlike Spravato, which is administered through nasal inhalation, Ketamine is typically introduced into the body through an IV for treatment-resistant depression. This method of administration allows for a controlled and personalized dose, adjusted to your specific needs.

You’ll find that the IV infusion process is typically done in a clinical setting, under the supervision of a healthcare provider. This ensures your safety and comfort throughout the procedure.

It’s also important to note that while Ketamine IV infusions can provide rapid relief of depressive symptoms, they also may have side effects such as temporary hallucinations or high blood pressure. It’s crucial to discuss these potential effects with your healthcare provider to make an informed decision.

Spravato (Esketamine)

You’ll notice that Spravato, or Esketamine, is administered quite differently than Ketamine, and it’s important to understand how this process works. Spravato is often prescribed to you as a nasal spray, which is inhaled under the supervision of a healthcare professional. Unlike Ketamine, which is often given intravenously, Spravato’s nasal administration allows for a more comfortable, non-invasive experience.

Here are a few key aspects of Spravato’s administration to keep in mind:

  • You’ll administer it yourself, under the watchful eye of your healthcare provider.
  • It’s taken via nasal spray, making the process less daunting than an IV infusion.
  • You’ll need to stay at the clinic for about 2 hours to monitor possible side effects, ensuring your safety throughout the process.

Mechanism of Action

Let’s move on to how Spravato and Ketamine work in your body. Understanding the mechanism of action for these two treatments can give you a clearer idea of their potential benefits.

How Ketamine Works

Diving into the mechanism of action, you’ll find that ketamine works by triggering the production of a brain chemical called glutamate. This chemical plays a crucial role in your brain’s neural activation. Ketamine increases glutamate production, leading to a rapid increase in the formation of new neural connections. This process is believed to help alleviate depressive symptoms and improve your mood.

Here’s how it might make you feel:

  • A sense of relief, as the depression lifts and you find yourself able to engage with life again.
  • A renewed sense of hope, as you realize that there’s a treatment that can help you combat depression.
  • Empowered, knowing you’re not helpless against your mental health challenges, thanks to ketamine’s unique mechanism of action.

How Spravato Works

Just as with ketamine, understanding how Spravato works is key to making an informed decision about your treatment options, and it begins with exploring its unique mechanism of action.

Spravato is a brand name for esketamine, a variant of the ketamine molecule. It works by blocking N-methyl-D-aspartate (NMDA) receptors in your brain. These receptors play a key role in mood regulation and synaptic plasticity, the ability of your brain’s connections to change and adapt.

Efficacy and Clinical Use

Spravato Vs Ketamine How Do They Compare clinical use

Let’s turn your attention to the clinical outcomes and efficacy of both Spravato and Ketamine.

It’s crucial to understand how these treatments perform and their implications in practical clinical use.

You’ll find out how each treatment measures up in terms of effectiveness and how they’re commonly used in the healthcare field.

Ketamine’s Clinical Outcomes

You’ll find that understanding the clinical outcomes of Ketamine, particularly its efficacy and usage in various treatments, provides valuable insight into its comparison with Spravato.

Results from clinical practice show that 45.5% of patients responded to ketamine treatment, with 27.3% achieving remission by the fourth infusion. Moreover, a subset of patients received long-term treatment without adverse effects.

Ketamine has shown to be a rapid-acting antidepressant, disrupting persistent depressive states and providing relief.

Off-label usage of ketamine for psychiatric disorders has increased since 2012, despite the controversy surrounding it.

Repeated doses of sub-anesthetic ketamine have proven to be relatively safe, with no significant negative clinical outcomes recorded.

Knowing these facts, you can make an informed comparison between Ketamine and Spravato.

Spravato’s Clinical Outcomes

Now that you’ve grasped Ketamine’s clinical outcomes, it’s time to delve into Spravato’s efficacy and clinical use, and see how it holds up in the comparison.

Spravato, a form of ketamine called esketamine, is FDA-approved for treating treatment-resistant depression. It’s typically prescribed alongside other antidepressants and its main benefit is its rapid effectiveness in relieving symptoms. You’ll find that Spravato reaches peak concentrations in your body within 20 to 40 minutes of nasal inhalation.

However, like any medication, it has potential side effects and risks, including the potential for abuse and dependence with prolonged use. Regular monitoring and evaluations are essential to ensure the safe and effective use of Spravato.

Side Effects and Safety Concerns

When considering Spravato vs Ketamine, you’ll also want to think about the potential side effects and safety concerns of each.

Any treatment option comes with its own set of risks and benefits.

Let’s take a look at what you might expect when it comes to these two options.

Ketamine Side Effects

In your journey to understand the comparison between Spravato and Ketamine, it’s important to examine the potential side effects and safety concerns associated with Ketamine. This powerful medication, while often effective, can result in a range of side effects. Some are mild and temporary, but others may be severe and longer-lasting.

To give you a clearer picture, here are a few potential side effects of Ketamine:

  • Changes in blood pressure and heart rate, which could be risky for people with certain heart conditions
  • Feelings of confusion, agitation, or hallucination during the initial recovery period
  • Nausea or vomiting, often manageable with anti-nausea medications

Spravato Side Effects

Just as you’ve explored the side effects of Ketamine, it’s equally important to delve into the potential side effects and safety concerns associated with Spravato.

Like all medications, Spravato can cause unwanted side effects. Common ones include dizziness, nausea, increased blood pressure, and vomiting. You might also feel sleepy or experience disorientation post-treatment. Some people have reported feeling unusual sensations or changes in perception.

While these side effects are typically short-term and fade away, it’s important to discuss them with your healthcare provider. Remember, each person’s reaction to medication varies, so what one person experiences mightn’t be the same for you.

Always consult with your healthcare provider about any concerns or questions you have regarding Spravato treatment.

Cost and Accessibility

Let’s shift our focus to the cost and accessibility of Spravato and Ketamine.

You may be asking about the financial aspect of these treatments and how easily you can access them.

We’ll tackle these critical questions in the following discussion.

Ketamine Cost

You’ll find that the cost of ketamine can vary considerably, with several factors influencing the final price. It’s important to note that expenses can range from $500 to $1000 per infusion, and it’s typically not covered by insurance as it’s not FDA-approved for mental health disorders.

Here are some key considerations: * The financial burden can feel overwhelming, especially when you’re already battling mental health issues. * The cost might deter you from seeking this potentially life-changing treatment. * The lack of insurance coverage can add to the stress, creating a feeling of injustice.

Despite these challenges, remember that investing in your mental health is invaluable, and with the right support, you can navigate these financial hurdles.

Spravato Cost and Insurance Coverage

When considering Spravato, you’re likely to find that the cost can run into several thousands of dollars, making insurance coverage a crucial factor in accessibility. The exact cost varies based on your dosage and frequency of treatment.

Given the expense, it’s advisable to consult with your insurance provider about coverage before embarking on this treatment. Many providers cover Spravato, especially as it’s FDA-approved for treatment-resistant depression. However, coverage can depend on your specific policy, so it’s vital to confirm.

If your insurance doesn’t include Spravato, don’t lose hope. Some clinics offer financial aid or payment plans to help make this groundbreaking treatment more accessible. Always ask about these options when discussing treatment plans with your healthcare provider.

Cost and AccessibilityThe Bottom Line: Which Is Right for You?

In determining your choice between Spravato and Ketamine, it’s crucial to consider both the cost and accessibility of each treatment option.

Spravato, being a newer FDA-approved treatment, may be covered by insurance, making it a potentially more affordable choice for some. However, insurance coverage varies greatly and it’s important to check with your provider.

Ketamine, on the other hand, has been used for decades for various medical purposes, but its use for mental health treatments isn’t typically covered by insurance. This could make it a more expensive option; however, it’s widely available and could be easier to access.

You should also consider:

  • How quickly you need relief: Spravato can provide rapid relief, but you may need to continue using it alongside other antidepressants. Ketamine has a longer track record and may offer more lasting relief.
  • The severity of your symptoms: If you’re suffering from treatment-resistant depression, Spravato might be a potent option. Ketamine also shows promise for treatment-resistant cases, and some patients have reported success with it.
  • Your personal comfort: You’ll need to stay at the clinic for at least two hours after a Spravato treatment due to possible side effects. Ketamine treatments may also have side effects, but these often resolve more quickly.

In the end, the right treatment for you’ll depend on your personal circumstances, your coverage, and your healthcare provider’s advice. It’s important to discuss all these factors thoroughly with your healthcare provider to make the best decision for your mental health.

Taking the Next Step: Discover Your Best Treatment Option

After weighing the pros and cons, and considering your personal needs, it’s time for you to take the next step and discover your best treatment option. Spravato and ketamine both have their benefits and potential side effects, and it’s crucial for you to understand how each could fit into your personal treatment plan.

Spravato, or esketamine, is an FDA-approved nasal spray that’s typically prescribed alongside other antidepressants for those suffering from treatment-resistant depression. Its rapid effectiveness is a significant advantage, but it’s important to remember that its long-term effects are still being studied.

On the other hand, ketamine therapy has shown promising results for those struggling with depression and anxiety. It’s been known to provide quick and lasting relief, helping to form new thought patterns and disrupt unhealthy ones. However, a small percentage of patients may experience mild side effects like light-headedness, grogginess, and nausea.

To determine which treatment option is best for you, consider factors like the severity of your symptoms, potential side effects, your personal health history, and your insurance coverage. It’s always recommended to discuss these considerations with your healthcare provider to make the most informed decision.

Remember, the ultimate goal is to find a treatment that provides relief and improves your quality of life.

PMC Heal is a premier choice for those seeking innovative and effective treatments for mental health conditions. Don’t hesitate to contact PMC Heal today for more information and to get started on your journey to wellness.

Frequently Asked Questions

What Is the Success Rate of Spravato Compared to Ketamine in Treating Mental Health Disorders?

When you’re comparing Spravato and Ketamine’s success rates in treating mental health disorders, it’s not cut and dry. Both have shown effectiveness, but individual response varies.

Spravato’s rapid action can bring relief faster, while Ketamine’s long-term impact on neural connections helps reset brain patterns.

It’s crucial to discuss these options with your healthcare provider to determine what’s best for you.

How Does the Cost of Spravato Treatment Compare to the Cost of Ketamine Therapy?

You’re asking about the cost comparison of Spravato treatment and Ketamine therapy.

Well, it varies widely. Spravato, being a newer, FDA-approved treatment, can be quite expensive, but insurance may cover part of it.

Ketamine therapy, often not covered by insurance, can also be costly out-of-pocket.

It’s crucial to consult with your healthcare provider or insurance company to understand potential costs better.

Are Both Spravato and Ketamine Covered by Most Health Insurance Plans?

Insurance coverage for both Spravato and Ketamine varies widely. It’s dependent on your individual policy and provider. While Spravato is FDA-approved for certain conditions, improving the chances of coverage, Ketamine’s coverage is less certain. You’ll need to directly contact your insurance provider to confirm coverage.

How Does the Administration Method of Spravato Differ From Ketamine Infusion?

You administer Spravato yourself under a healthcare professional’s supervision. It’s a nasal spray, so you’ll take puffs in each nostril.

Ketamine infusion, on the other hand, is a bit more complex. Healthcare professionals administer it intravenously in a controlled setting.

Can Spravato and Ketamine Be Used in Conjunction With Other Mental Health Treatments?

Yes, both Spravato and Ketamine can be used alongside other mental health treatments.

Spravato is often prescribed in combination with other antidepressants.

Similarly, Ketamine therapy is typically administered with therapeutic support.

It’s crucial, however, that you consult with your healthcare provider before combining these treatments to ensure safety and effectiveness.

They’ll help you understand the potential benefits and risks.


In summary, the potential offered by both ketamine and Spravato in treating mental health disorders is indeed promising. The decision between the two hinges on your individual needs, possible side effects, and financial considerations. Consulting with your healthcare provider is paramount for a thorough evaluation of the benefits and risks associated with each option.

It’s important to acknowledge that mental health treatment is not a one-size-fits-all solution. Persistence in exploring various options is key to discovering what suits you best.

Maintain hope throughout your journey towards improved mental health – a goal that is entirely attainable. If you’re seeking expert guidance in the realm of psychedelics treatment, consider reaching out to PMC Heal, a trusted authority in this field. Your path to wellness starts with informed decisions, and PMC Heal is here to provide the support and expertise you need. Take the first step towards a brighter future by connecting with them today.